انواع ضدآندروژن و مقدار مصرف:

 

,1 mg(0.2 ml) a day S.C

Lupron (Tap pharmaceyticals Usa: 14 mg/2.8 ml vials)

Leuprolide acetate

0.5 mg every 8h, S.C. tor 7 days, then bilateral nasal spray beto before and after the 3 meals a day (= 12 inhalations)

Super fact, Inject able and nasal (Hoechst)

Buserelin

1000 mg 2/week i.m.

USA: Delautin

Hydroxyprogestrone capraote

100-200 orally on alternate days 500mg/day i.m.

200-300 mg/day orally (Endometrial canser)

USA: Provera, Depo. Provera

Medroxyprogestrone acetate

160 mg/day

in 4 divided doses

40-320 mg/day orally

in divided doses

Megace ( mead Johnson, USA: 20 and 40 mg tablets)

Megestrol acetate

10-20 mg orally

twice daily

USA: Nolvadex, Stuart Pharmaceutical

Tamoxifen

250 mg x 2-4/day

Administer adrenal replacement therapy

(hydrocortisone: 40-50 mg/day in divided doses)

USA: Cytraden,Ciba Geigy

Aminoglutethimide

 

عوارض : تهوع، خونريزي رحمي ،  اختلال قاعدگي ،  درد استخوان در محل تومور ،  رتينوپاتي ،  سرگيجه ،  ادم ،  کلستاز ،  سرکوب مغز استخوان