198 Non – Melanoma Skin Cancer
37.Non – Melanoma Skin Cancer
37.1 General Considerations
Non-metanoma skin cancer- primarily basal and squamous cell carcinoma – is the most common human malignancy. Treatment includes surgical methods such as local excission, cryosurgery, laser therapy, curettage, electrodissication or Mohs micrographic surgery, but also radiation, photodynamic therapy, immunotherapy with interferon alpha, as well as local and systemic chemotherapy.
Literature: for review e.g.
De ROSA and BENTLEY, Pharm. Res. 17 (2000): 1447 – 1455
(photodynamic therapy)
THISSEN et al, Arch. Dermatol. 135 (1999): 1177-1183 (systemic treatment modalities for basal cell carcinomas )
Vander STRATEN et al, Adv. Dermatol. 16 (2000): 299-318 (pharmacologic therapy of basal cell carcinoma)
37.2 Single agent chemotherapy
Methotrexate (40 mg/m2 i.v. bolus, weekly) for squamous cell carcinoma and cisplatin (100 mg/m2 every 3 weeks) for basal cell carcinoma
37.3 Combination chemotherapy
37.3.1 Cisplatin + doxorubicin (f or squamous cell carcinoma)
|
Cisplatin 75 mg/m2 i.v.( 1 h inf) d 1 |
|
Doxorubicin 50 mg/m2 i.v.( 24 h inf) d 1 |
To be repeated every 3 weeks
Literature:
GUTHRIE et al, J. Clin. Oncol. 8 (1990): 342 – 346
37.3.2. Cisplatin + 5- fluorouracil ( for squamous cell and basal carcinoma)
|
Cisplatin 100 mg/m2 i.v. ( 1-2 h inf) d 1 |
|
5-Fluorouracil 1000mg/m2 i.v. (24 h inf) d 1-5 |
To be repeated every 3 weeks
Literature:
KHANSUR et al, Cancer 67 (1991): 2020-2032
37.4 Merkel cell carcinoma
See 36,8