Hodgkin’s disease, bone marrow aspirate. A classic binucleate Reed-Sternberg cell is seen in the center of the field. The nuclei are mirror image, the nucleoli are large and there is intense cellular basophilia as well as marked cytoplasmic vacuolization.

 

Mononuclear Hodgkin’s cell, bone marrow aspirate.

 

Hodgkin’s disease, H&E stained bone marrow biopsy. A classical binucleate Reed-Sternberg cell is seen in the center of the field. The surrounding cellular infiltrate is interspersed with some fibrous tissue and other stroma.

 

Hodgkin’s disease, H&E stained bone marrow biopsy. Complete replacement of the normal bone marrow elements is noted. The process contains both cellular elements and fibrosis.

 

Hodgkin’s disease, mixed cellularity (HDMC), lymph node. A binucleate Reed-Sternberg cell is seen near the center of the field. There is some fibrosis. Lymphocytes, plasma cells, and eosinophils can also be appreciated.

 

Nodular sclerosing Hodgkin’s disease (HDNS), H&E stain. Hodgkin’s cells, lacunar cells, lymphoid, and histiocytic cells are all seen in this slide.

 

Hodgkin’s disease associated with AIDS, bone marrow biopsy, H&E. Total replacement of normal bone marrow by an abnormal infiltrate including two Reed-Sternberg cells (top right).