BRAIN CANCER

 

Regimen/Number

Of Patients

Drug Dose and Route

Leukopenia/

Neutropenia

Toxicity

Anemia

Toxicity

Other

Grade III-IV Toxicities

Emetogenic

Potential

Consequences of

Adverse Event(s)

BCNU (Carmustine)

(Levin VA, et al,

J Neurosurg,

1985;63:218-23)

 

N= 72

BCNU 200 mg/m2 IV day 1

Repeat cycle every 6-8 weeks

Leukopenia

Grade III 4%

Grade IV 1%

 

Thrombocytopenia  21 %

Nausea /Vomiting 5 %

Day 1 –

Level 4

 

PCV

(Levin VA, et al,

J Neurosurg,

1985;63:218-23)

 

N= 76

 

Procarbazine 60 mg/m2 /d PO day 8-21

Lomustine 110 mg/m2  PO day 1 only

Vincristine 1.4 mg/m2 IV on days 8 and 29

Repeat cycle every 6-8 weeks

Leukopenia

Grade III 15%

Grade IV 8%

 

Grade III-IV 1%

Thrombocytopenia 26%

Nausea /Vomiting 11 %

Neuropathy 8 %

 

Day 1 –

Level 5

Day 8-21-

Level 4

 

Temozolomide

(Yung WKA, et al .

J Clin Oncol.

1999;17:2762-71

 

 

N= 162

 

Temozolomide 150 mg/m2 /d PO days 1-5*

Repeat cycle every 28 days

 

For patients who have previously received

any chemotherapy, Dose for chemotherapy-

naïve patients was 200 mg/m2/d.

Neutropenia 2%

Leukopenia 2%

 

Fever 2%

Thrombocytopenia 6%
Nausea 10%

Vomiting 6%

Headache 6%

Asthenia 6%

Fatigue 5%

 

Day 1-5-

Level 1