GYNECOLOGY : VULVAR

Regimen/Number

Of Patients

Drug Dose and Route

Leukopenia/

Neutropenia

Toxicity

Anemia

Toxicity

Other

Grade III-IV Toxicities

Emetogenic

Potential

Consequences of

Adverse Event(s)

Bleomycin

CCNU

Methotrexate

(Wagenaar HC, et al,

Gynecol Oncol,

2001; 81: 348-54)

N= 25

Bleomycin 5 mg/d IM days 1-5 during

the first week and days 1, 4 during

subsequent 5 weeks

CCNU 40 mg/d PO days 5-7

Methotrexate 15 mg/d PO days 1, 4

during the first week and day 1 during

subsequent 5 weeks

Repeat 6-week cycle every 49 days

Appropriate premedications listed in Section 2,

Commonly Used Premedication Regimens

WHO Toxicity

WBC

Grade III 4%

Grade IV 4%

WHO Toxicity:

Hemoglobin 24%

WHO Toxicity:

Neutropenic Fever

(Grade III) 4%

Infection (Grade III) 4%

Mucositis 12%

Pulmonary (Grade IV) 4%

Alopecia (Grade III) 8%

Neurotoxicity,

Stage of Consciousness

(Grade III) 4%

Thrombocytopenia 12 %

Days 1- 4

Level 1

Days 5 – 7 –

Level 4

2 toxic deaths

(1 infection ,

1 pulmonary)