GYNECOLOGY : UTERINE SARCOMA

Regimen/Number

Of Patients

Drug Dose and Route

Leukopenia/

Neutropenia

Toxicity

Anemia

Toxicity

Other

Grade III-IV Toxicities

Emetogenic

Potential

Consequences of

Adverse Event(s)

Ifosfamide

(Sutton G, et al,

Gynecol Oncol,

2000;79:147-153

N= 102

Ifosfamide 1500 mg/m² /d IV days 1-5

Mesna uroprotection at equivalent doses to

Ifosfamide via IV continuous ifusion

Repeat cycle every 21 days

Neutropenia

Grade III 28%

Grade IV 31%

Granulocytopenia

Grade III 8%

Grade IV 28%

Grade III-IV 8%

Thrombocytopenia 5%

Nausea/Vomiting

(Grade III) 4%

Other Gastrointestinal

(Grade IV ) 1%

Creatinine Elevation

(Grade III) 2%

Neurologic –Central

(Grade III) 19%

Neurologic – Peripheral

(Grade IV) 1%

Hematuria (Grade III) 1%

Day 1-

Level 3

Treatment –related

deaths 5%