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SARCOMA: UNCLASSIFIED
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Regimen/Number Of Patients |
Drug Dose and Route |
Leukopenia/ Neutropenia Toxicity |
Anemia Toxicity |
Other Grade III-IV Toxicities |
Emetogenic Potential |
Consequences of Adverse Event(s) |
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AD (Antman K, et al. J Clin Oncol. 1993;11:1276-85)
N = 170 |
Doxorubicin 15 mg/m2/d continuous infusion days 1-4 Dacarbazine 250 mg/m2/d IV continuous infusion days 1-4 Repeat cycle every 21 days |
Neutropenia Grade III-IV 38% Leukopenia Grade III-IV 32% |
Grade III-IV 6.5 % |
Nausea/ Vomiting 9 % Thrombocytopenia 4% Cardiac 1 % Mucositis/ Stomatitis 7% Diarrhea < 1 %
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Days 1 – 4 – Level 5 |
1 death due to pulmonary embolism
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DI (Schutte J, et al. Eur J Cancer. 1990;26:558-61)
N = 175 |
Doxorubicin 50 mg/m2 IV bolus, day 1 Ifosfamide 5000 mg/m2/d IV continuous Infusion followed doxorubicin, day 1 Mesna 600 mg/m2 IV bolus before ifosfamide, 2500 mg/m2/d IV continuous infusion with ifosfamide, 1250 mg/m2 IV over 12 hours following ifosfamide Repeat cycle every 21 days |
Leukopenia Grade III-IV 73% Grade IV 34% |
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Neutropenic Fever 2% Documented infection 6% Fever 2 % Thrombocytopenia * 5% Nausea/Vomiting 41% Alopecia 71% Diarrhea 2% Oral 3% Renal 2 % Cardiac 1 % Consciousness 3% Hematuria 2 % * < 75.000 /mm3 |
Day 1 – Level 4 |
Toxic death 1 % Modify treatment (of courses) 26% Discontinue teatment 11 % |
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Doxoribicin (Nielsen OS, et al. BR J Cancer. 1998;78:1634-39)
N = 104 |
Doxorubicin 75 mg/m2 IV day 1 Repeat cycle every 21 days |
Neutropenia Grade III 30% Grade IV 21% Leukopenia Grade III 30% Grade IV 8% |
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Infection 3% Nausea/Vomiting 13 % Thrombocytopenia 2 % Mucositis 6 % Cardiotoxicity 1 %
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Day 1 – Level 4 |
Dose intensity 97 % 1 patient death due to cardiotoxicity
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IE (Edmonson JH, et al. J Natl Cancer Inst. 1989;89:863-66)
N = 44 |
Mesna at 20% of ifosfamide dose prior to ifosfamide, at completion of etoposide infusion, and then every 4 hours for a further 3 doses Ifosfamide 2500 mg/m2/d IV days 1-3, followed by Etoposide 100 mg/m2/d IV days 1-3 Repeat cycle every 28 days |
Leukopenia Grade IV 38% |
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Neutropenic Fever During Leukopenia 5 % Nausea/Vomiting * 70 % Thrombocytopenia 3 % Alopecia (significant)* 85% Renal Failure* 2 %
* Grade unknown |
Days 1 – 3 – Level 4 |
No toxic mortality
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