GYNECOLOGY: ENDOMETRIAL CANCER

Regimen/Number

Of Patients

Drug Dose and Route

Leukopenia/

Neutropenia

Toxicity

Anemia

Toxicity

Other

Grade III-IV Toxicities

Emetogenic

Potential

Consequences of

Adverse Event(s)

AP

(Barrett RJ, et al,

Am J Clin Oncol.

1993;16:494-96)

N= 30

Doxorubicin 60 mg/m² IV day 1,  followed by

Cisplatin 60 mg/m² IV day 1 given 12 hous

after doxorubicin

Repeat cycle every 28 days

Leukopenia

Grade III 17 %

Grade IV 43%

Grade III 16%

Thrombocytopenia 20 %

Nausea / Vomiting *  3%

Severe

Day 1-

level 5

No patient died or

discontinued therapy

due to toxicity

Doxorubicin

(Marrow CP, et al,

Gynecol Onocl.

1990;36:166-71)

N= 92

Doxorubicin 60 mg/m² IV day 1

Repeat cycle every 21 days

Note: Initial dose was 45 mg/m², escalated

to  60 mg/

Leukopenia

Grade III  23%

Neutropenia

Grade III 8 %

Gastrointestinal 3 %

Day 1-

level 3

Toxic mortality 3 %